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Compound fights virus behind MERS K22 appears to block virus from spreading in humans

GENEVA, May 30, (Agencies): An international team of scientists say they have identified a compound that can fight coronaviruses, responsible for the SARS and MERS outbreaks, which currently have no cure. Coronaviruses affect the upper and lower respiratory tracts in humans. They are the reason for up to a third of common colds. A more severe strain of the virus, thought to have come from bats, triggered the global SARS (Severe Acute Respiratory Syndrome) epidemic in 2002, which killed nearly 800 people.

The Middle East Respiratory Syndrome (MERS) is a new strain discovered in Saudi Arabia in 2012 and thought to have originated in camels. More deadly but less contagious, it has so far killed 193 people out of 636 confirmed cases. Now, a team of scientists led by Edward Trybala from the University of Gothenburg in Sweden and Volker Thiel from the University of Bern, have discovered a compound called K22, which appears to block the ability of the virus to spread in humans. “This finding is important in light of the fact that some emerging coronaviruses, such as SARS and MERS ... are potential pandemic-causing pathogens,” Trybala said in an email to AFP. In “our work we found a novel strategy to combat these viruses,” he added.

The team screened 16,671 different compounds before realising that K22 could combat a weak form of coronavirus that causes mild cold-like symptoms. They then went on to show that it can fight more serious strains, including SARS and MERS. In an article for specialist journal “PLOS Pathogens”, the scientists explained that the virus reproduces in the cells that line the human respiratory system.

The virus takes over the membranes that separate different parts of human cells, reshaping them into a sort of protective armour in order to start its production cycle, and so creating “viral factories,” Trybala told AFP. K22 acts at an early stage in this process, preventing the virus from taking control of the cell membranes and so opening up “new treatment possibilities,” he said. “The results confirm that the use of the membrane of the host cell is a crucial step in the life-cycle of the virus,” the researchers wrote.

Their work shows that “the process is highly sensitive and can be influenced by antiviral medications”. They said the recent SARS epidemic and MERS outbreak mean there should be urgent investment in testing K22 outside the laboratory and developing medicines. While K22 still has a way to go before it can be tested on humans, Trybala still believes “that identification of this new strategy of combating coronaviruses will aid to develop an effective and safe antiviral drug”. Earlier this month, experts gathered in Geneva but the World Health Organization confirmed that MERS was spreading but had yet to reach the level of global emergency.

Most of the MERS cases and deaths so far have been in Saudi Arabia, but the virus has been imported to more than a dozen other countries. All of those cases have involved people who became ill while in the Middle East. Saudi Arabia’s Health Ministry says 13 people have died over the last two weeks from the Middle Eastern respiratory virus.

The ministry says 186 people in total have died from the virus since it was discovered in 2012. The ministry said late Wednesday another 565 people had contracted the virus in Saudi Arabia. The recent figures indicate that the rate of infections and deaths may have slightly dipped in the last two weeks after a sharp rise in infections and deaths in April and the first half of May. On Thursday, Iran has suffered its first fatality from the Middle Eastern respiratory virus, its official news agency reported, a day after the first cases in Islamic Republic were publicized. The IRNA news agency quoted Health Ministry official Mohammad Mahdi Gouya as saying the virus killed a 53- year-old woman in Kerman, a city in southeastern Iran.

On Wednesday, the daily newspaper Hamshahri quoted Gouya as saying two sisters in Kerman contracted the virus. “The women’s immune system had with the disease due to chronic illness. (They were) unable to fight the virus.” Gouya told IRNA. It remains unclear how the two women became infected with MERS and authorities have given no further details.

MERS is part of the coronavirus family of viruses, which includes the common cold and SARS, or severe acute respiratory syndrome. MERS can cause symptoms including fever, breathing problems, pneumonia and kidney failure. The virus, first reported in Saudi Arabia, has seen cases spread across the world since its discovery two years ago. The World Health Organization said Wednesday that it had documented 636 laboratory-confirmed cases of MERS worldwide, including 193 deaths. Gouya told IRNA that measures have been taken to provide information to pilgrims who visit Saudi Arabia for pilgrimages to the Islamic holy city of Makkah

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